Drug interactions
Avapritinib + Ergotamine
Severity: Minor
Avapritinib and Ergotamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib is a CYP3A4 substrate. Ergotamine is mainly a CYP3A4 substrate and not a recognized inhibitor, so the interaction is unlikely to be clinically important.
What this interaction means in plain words
Avapritinib and Ergotamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Avapritinib belongs to Oncology; Ergotamine belongs to Central Nervous System.
Why it happens
No established CYP3A4 inhibition by ergotamine; effect on avapritinib exposure is theoretical.
What to do
No routine adjustment is needed; monitor for avapritinib adverse effects such as cognitive effects and bleeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Ergotamine?
MediHelp rates the interaction as minor. Avapritinib and Ergotamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Avapritinib is a CYP3A4 substrate. Ergotamine is mainly a CYP3A4 substrate and not a recognized inhibitor, so the interaction is unlikely to be clinically important.
How serious is the interaction between Avapritinib and Ergotamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for avapritinib adverse effects such as cognitive effects and bleeding.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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