Drug interactions
Avapritinib + Fexofenadine
Severity: Minor
Avapritinib and Fexofenadine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib can cause cognitive effects and somnolence, while fexofenadine is essentially non-sedating. Additive sedation is therefore unlikely to be clinically significant.
What this interaction means in plain words
Avapritinib and Fexofenadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Avapritinib belongs to Oncology; Fexofenadine belongs to Respiratory.
Why it happens
Theoretical additive CNS effects; fexofenadine has negligible central penetration.
What to do
No specific action is needed; monitor cognition and drowsiness as part of avapritinib therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Avapritinib and Fexofenadine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fexofenadine
- Danicopan + Fexofenadine Moderate
- Erdafitinib + Fexofenadine Moderate
- Fexofenadine + Glecaprevir / pibrentasvir Moderate
- Fexofenadine + Grapefruit Moderate
- Fexofenadine + Juice Moderate
- Acrivastine + Fexofenadine Minor
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Fexofenadine?
MediHelp rates the interaction as minor. Avapritinib and Fexofenadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Avapritinib can cause cognitive effects and somnolence, while fexofenadine is essentially non-sedating. Additive sedation is therefore unlikely to be clinically significant.
How serious is the interaction between Avapritinib and Fexofenadine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed; monitor cognition and drowsiness as part of avapritinib therapy.
What other medicines interact with Fexofenadine?
MediHelp also lists interactions of Fexofenadine with, for example, Danicopan, Erdafitinib, Glecaprevir / pibrentasvir. The full list is on the Fexofenadine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
