Drug interactions
Avapritinib + Fluconazole
Severity: Major
Avapritinib and Fluconazole: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole moderately inhibits CYP3A4, which is the main route of avapritinib clearance. Higher avapritinib exposure raises the risk of cognitive effects, intracranial hemorrhage, and other toxicities.
What this interaction means in plain words
Avapritinib and Fluconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Avapritinib belongs to Oncology; Fluconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4-mediated metabolism of avapritinib.
What to do
Avoid if possible. If a moderate CYP3A4 inhibitor must be used, reduce the avapritinib dose per labeling and monitor for adverse effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Fluconazole?
MediHelp rates the interaction as major. Avapritinib and Fluconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluconazole moderately inhibits CYP3A4, which is the main route of avapritinib clearance. Higher avapritinib exposure raises the risk of cognitive effects, intracranial hemorrhage, and other toxicities.
How serious is the interaction between Avapritinib and Fluconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If a moderate CYP3A4 inhibitor must be used, reduce the avapritinib dose per labeling and monitor for adverse effects.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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