Drug interactions
Avapritinib + Loratadine
Severity: Minor
Avapritinib and Loratadine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib can cause cognitive effects and somnolence, which may be added to by loratadine. Loratadine is only weakly sedating, so the additive effect is small.
What this interaction means in plain words
Avapritinib and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Avapritinib belongs to Oncology; Loratadine belongs to Respiratory.
Why it happens
Additive CNS effects.
What to do
Monitor for drowsiness and cognitive changes, and counsel the patient on driving and machinery.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Loratadine
- Acrivastine + Loratadine Moderate
- Amobarbital + Loratadine Moderate
- Fentanyl + Loratadine Moderate
- Isocarboxazid + Loratadine Moderate
- Levoketoconazole + Loratadine Moderate
- Loratadine + Mavacamten Moderate
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Loratadine?
MediHelp rates the interaction as minor. Avapritinib and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Avapritinib can cause cognitive effects and somnolence, which may be added to by loratadine. Loratadine is only weakly sedating, so the additive effect is small.
How serious is the interaction between Avapritinib and Loratadine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for drowsiness and cognitive changes, and counsel the patient on driving and machinery.
What other medicines interact with Loratadine?
MediHelp also lists interactions of Loratadine with, for example, Acrivastine, Amobarbital, Fentanyl. The full list is on the Loratadine page.
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