Drug interactions
Avapritinib + Palbociclib
Severity: Moderate
Avapritinib and Palbociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palbociclib may modestly increase avapritinib exposure through weak CYP3A4 inhibition. Avapritinib has dose-related cognitive effects, intracranial bleeding risk and edema, so higher levels matter.
What this interaction means in plain words
Avapritinib and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Palbociclib belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by palbociclib reduces avapritinib clearance.
What to do
Monitor for avapritinib toxicity, including cognitive changes, edema and bleeding, and for neutropenia from the combination. Reduce the avapritinib dose if adverse effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Palbociclib
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Palbociclib?
MediHelp rates the interaction as moderate. Avapritinib and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Palbociclib may modestly increase avapritinib exposure through weak CYP3A4 inhibition. Avapritinib has dose-related cognitive effects, intracranial bleeding risk and edema, so higher levels matter.
How serious is the interaction between Avapritinib and Palbociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for avapritinib toxicity, including cognitive changes, edema and bleeding, and for neutropenia from the combination. Reduce the avapritinib dose if adverse effects develop.
What other medicines interact with Palbociclib?
MediHelp also lists interactions of Palbociclib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Palbociclib page.
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