Drug interactions
Avapritinib + Pregabalin
Severity: Moderate
Avapritinib and Pregabalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib can cause cognitive adverse effects and somnolence, and pregabalin is also sedating. Taken together they may worsen drowsiness, confusion and memory problems.
What this interaction means in plain words
Avapritinib and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Pregabalin belongs to Central Nervous System.
Why it happens
Additive CNS-depressant and cognitive effects (pharmacodynamic).
What to do
Monitor for sedation and cognitive changes, and consider reducing the pregabalin dose if symptoms develop. Counsel patients on driving and machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Avapritinib and Pregabalin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Pregabalin
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Pregabalin?
MediHelp rates the interaction as moderate. Avapritinib and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib can cause cognitive adverse effects and somnolence, and pregabalin is also sedating. Taken together they may worsen drowsiness, confusion and memory problems.
How serious is the interaction between Avapritinib and Pregabalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and cognitive changes, and consider reducing the pregabalin dose if symptoms develop. Counsel patients on driving and machinery.
What other medicines interact with Pregabalin?
MediHelp also lists interactions of Pregabalin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Pregabalin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
