Drug interactions
Avapritinib + Ranolazine
Severity: Moderate
Avapritinib and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine is a weak CYP3A4 inhibitor and may modestly increase avapritinib concentrations. Higher exposure could increase avapritinib toxicities such as cognitive effects, intracranial hemorrhage and edema.
What this interaction means in plain words
Avapritinib and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Ranolazine belongs to Cardiovascular.
Why it happens
Weak inhibition of CYP3A4-mediated avapritinib metabolism.
What to do
Monitor for avapritinib adverse effects, especially cognitive changes and bleeding, and reduce the dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Ranolazine?
MediHelp rates the interaction as moderate. Avapritinib and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ranolazine is a weak CYP3A4 inhibitor and may modestly increase avapritinib concentrations. Higher exposure could increase avapritinib toxicities such as cognitive effects, intracranial hemorrhage and edema.
How serious is the interaction between Avapritinib and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for avapritinib adverse effects, especially cognitive changes and bleeding, and reduce the dose if toxicity occurs.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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