Drug interactions
Avapritinib + Risperidone
Severity: Minor
Avapritinib and Risperidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib causes CNS effects including cognitive impairment, dizziness and somnolence, which may add to risperidone sedation. Risperidone is not a meaningful CYP3A4 inhibitor, so the legacy enzyme mechanism is not credible. The concern is mainly additive CNS effects.
What this interaction means in plain words
Avapritinib and Risperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Avapritinib belongs to Oncology; Risperidone belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects; no established pharmacokinetic interaction.
What to do
Monitor for sedation and cognitive changes and reduce doses if impairment develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Risperidone?
MediHelp rates the interaction as minor. Avapritinib and Risperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Avapritinib causes CNS effects including cognitive impairment, dizziness and somnolence, which may add to risperidone sedation. Risperidone is not a meaningful CYP3A4 inhibitor, so the legacy enzyme mechanism is not credible. The concern is mainly additive CNS effects.
How serious is the interaction between Avapritinib and Risperidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and cognitive changes and reduce doses if impairment develops.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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