Drug interactions
Avapritinib + Sevoflurane
Severity: Moderate
Avapritinib and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib can cause cognitive effects and somnolence, which may add to the sedative effect of sevoflurane. Patients may have delayed recovery or deeper sedation than expected.
What this interaction means in plain words
Avapritinib and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects; the mechanism of avapritinib's CNS effects is not fully established.
What to do
Titrate sevoflurane to depth-of-anesthesia monitoring and monitor postoperative recovery and cognition.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Sevoflurane?
MediHelp rates the interaction as moderate. Avapritinib and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib can cause cognitive effects and somnolence, which may add to the sedative effect of sevoflurane. Patients may have delayed recovery or deeper sedation than expected.
How serious is the interaction between Avapritinib and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate sevoflurane to depth-of-anesthesia monitoring and monitor postoperative recovery and cognition.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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