Drug interactions
Avapritinib + Trazodone
Severity: Moderate
Avapritinib and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause CNS effects such as sedation, and avapritinib can cause cognitive adverse effects including confusion, memory impairment and drowsiness. Combined use may worsen somnolence and cognitive impairment.
What this interaction means in plain words
Avapritinib and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Trazodone belongs to Central Nervous System.
Why it happens
Additive CNS depressant and cognitive effects; no significant pharmacokinetic interaction is established.
What to do
Monitor for excessive sedation and cognitive changes, and counsel patients about driving and operating machinery. Reduce trazodone dose if cognitive symptoms emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Trazodone?
MediHelp rates the interaction as moderate. Avapritinib and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause CNS effects such as sedation, and avapritinib can cause cognitive adverse effects including confusion, memory impairment and drowsiness. Combined use may worsen somnolence and cognitive impairment.
How serious is the interaction between Avapritinib and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and cognitive changes, and counsel patients about driving and operating machinery. Reduce trazodone dose if cognitive symptoms emerge.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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