Drug interactions
Avapritinib + Zileuton
Severity: Moderate
Avapritinib and Zileuton: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib is a CYP3A4 substrate, and zileuton is a weak CYP3A4 inhibitor that may modestly raise avapritinib exposure. Labeling advises avoiding strong and moderate inhibitors, but weak inhibitors are expected to have limited effect.
What this interaction means in plain words
Avapritinib and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Zileuton belongs to Respiratory.
Why it happens
Weak CYP3A4 inhibition by zileuton reduces avapritinib clearance.
What to do
Monitor for avapritinib toxicity, such as cognitive effects, edema and bleeding. Reduce the avapritinib dose if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zileuton
- Fezolinetant + Zileuton Contraindicated
- Pimozide + Zileuton Contraindicated
- Alosetron + Zileuton Major
- Clozapine + Zileuton Major
- Lomitapide + Zileuton Major
- Lonafarnib + Zileuton Major
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Zileuton?
MediHelp rates the interaction as moderate. Avapritinib and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib is a CYP3A4 substrate, and zileuton is a weak CYP3A4 inhibitor that may modestly raise avapritinib exposure. Labeling advises avoiding strong and moderate inhibitors, but weak inhibitors are expected to have limited effect.
How serious is the interaction between Avapritinib and Zileuton?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for avapritinib toxicity, such as cognitive effects, edema and bleeding. Reduce the avapritinib dose if adverse effects emerge.
What other medicines interact with Zileuton?
MediHelp also lists interactions of Zileuton with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Zileuton page.
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