Drug interactions
Azelastine-fluticasone + Prochlorperazine
Severity: Minor
Azelastine-fluticasone and Prochlorperazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azelastine can add to the sedation produced by prochlorperazine. Systemic absorption from the nasal spray is low, so the effect is usually small.
What this interaction means in plain words
Azelastine-fluticasone and Prochlorperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azelastine-fluticasone belongs to Respiratory; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive CNS depression from H1-antihistamine and phenothiazine activity.
What to do
Counsel patients about additive drowsiness and caution with driving. Reduce use of the spray if excessive sedation occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Azelastine-fluticasone with Prochlorperazine?
MediHelp rates the interaction as minor. Azelastine-fluticasone and Prochlorperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Azelastine can add to the sedation produced by prochlorperazine. Systemic absorption from the nasal spray is low, so the effect is usually small.
How serious is the interaction between Azelastine-fluticasone and Prochlorperazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about additive drowsiness and caution with driving. Reduce use of the spray if excessive sedation occurs.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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