Drug interactions
Bazedoxifene-conjugated estrogens + Posaconazole
Severity: Moderate
Bazedoxifene-conjugated estrogens and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole is a strong CYP3A4 inhibitor and may raise exposure to estrogens and bazedoxifene. Higher estrogen levels could increase estrogen-related adverse effects such as breast tenderness, fluid retention and thromboembolic risk.
What this interaction means in plain words
Bazedoxifene-conjugated estrogens and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bazedoxifene-conjugated estrogens belongs to Endocrine; Posaconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4-mediated metabolism reduces clearance of estrogens and bazedoxifene.
What to do
Monitor for estrogenic adverse effects during concurrent use, particularly for prolonged azole courses. Reassess the need for the hormone therapy or reduce the dose if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bazedoxifene-conjugated estrogens
- Anastrozole + Bazedoxifene-conjugated estrogens Contraindicated
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Antithrombin alfa + Bazedoxifene-conjugated estrogens Major
- Antithrombin iii + Bazedoxifene-conjugated estrogens Major
- Bazedoxifene-conjugated estrogens + Bemiparin Major
- Bazedoxifene-conjugated estrogens + Carbamazepine Major
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Bazedoxifene-conjugated estrogens with Posaconazole?
MediHelp rates the interaction as moderate. Bazedoxifene-conjugated estrogens and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole is a strong CYP3A4 inhibitor and may raise exposure to estrogens and bazedoxifene. Higher estrogen levels could increase estrogen-related adverse effects such as breast tenderness, fluid retention and thromboembolic risk.
How serious is the interaction between Bazedoxifene-conjugated estrogens and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogenic adverse effects during concurrent use, particularly for prolonged azole courses. Reassess the need for the hormone therapy or reduce the dose if symptoms occur.
What other medicines interact with Bazedoxifene-conjugated estrogens?
MediHelp also lists interactions of Bazedoxifene-conjugated estrogens with, for example, Anastrozole, Ospemifene, Antithrombin alfa. The full list is on the Bazedoxifene-conjugated estrogens page.
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