Drug interactions
Bedaquiline + Mirtazapine
Severity: Major
Bedaquiline and Mirtazapine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bedaquiline prolongs the QT interval, and its labeling cautions against use with other QT-prolonging drugs. Mirtazapine may add to this effect and increase the chance of serious arrhythmia.
What this interaction means in plain words
Bedaquiline and Mirtazapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bedaquiline belongs to Anti Bacterial; Mirtazapine belongs to Central Nervous System.
Why it happens
Additive prolongation of cardiac repolarization (QT interval).
What to do
Use an ECG at baseline and at regular intervals during therapy, and keep electrolytes normal. Consider an alternative to mirtazapine if the QT interval lengthens significantly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Bedaquiline
- Bedaquiline + Ziprasidone Contraindicated
- Alfuzosin + Bedaquiline Major
- Amiodarone + Bedaquiline Major
- Amisulpride + Bedaquiline Major
- Amitriptyline + Bedaquiline Major
- Amobarbital + Bedaquiline Major
Frequently asked questions
Can I take Bedaquiline with Mirtazapine?
MediHelp rates the interaction as major. Bedaquiline and Mirtazapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bedaquiline prolongs the QT interval, and its labeling cautions against use with other QT-prolonging drugs. Mirtazapine may add to this effect and increase the chance of serious arrhythmia.
How serious is the interaction between Bedaquiline and Mirtazapine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an ECG at baseline and at regular intervals during therapy, and keep electrolytes normal. Consider an alternative to mirtazapine if the QT interval lengthens significantly.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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