Drug interactions
Bedaquiline + Risperidone
Severity: Major
Bedaquiline and Risperidone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bedaquiline prolongs the QT interval and risperidone carries a smaller QT risk, so combined use may increase the risk of torsades de pointes. The risk grows with electrolyte disturbance or other QT-prolonging drugs.
What this interaction means in plain words
Bedaquiline and Risperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bedaquiline belongs to Anti Bacterial; Risperidone belongs to Central Nervous System.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Obtain a baseline ECG and repeat it regularly during treatment, and correct potassium, calcium and magnesium. Consider alternatives or stop the QT-prolonging drug if the QTc exceeds a safe limit.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Bedaquiline
- Bedaquiline + Ziprasidone Contraindicated
- Alfuzosin + Bedaquiline Major
- Amiodarone + Bedaquiline Major
- Amisulpride + Bedaquiline Major
- Amitriptyline + Bedaquiline Major
- Amobarbital + Bedaquiline Major
Frequently asked questions
Can I take Bedaquiline with Risperidone?
MediHelp rates the interaction as major. Bedaquiline and Risperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bedaquiline prolongs the QT interval and risperidone carries a smaller QT risk, so combined use may increase the risk of torsades de pointes. The risk grows with electrolyte disturbance or other QT-prolonging drugs.
How serious is the interaction between Bedaquiline and Risperidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and repeat it regularly during treatment, and correct potassium, calcium and magnesium. Consider alternatives or stop the QT-prolonging drug if the QTc exceeds a safe limit.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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