Drug interactions
Belumosudil + Enzalutamide
Severity: Moderate
Belumosudil and Enzalutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide, a strong CYP3A4 inducer, lowers belumosudil exposure and may reduce control of chronic graft-versus-host disease.
What this interaction means in plain words
Belumosudil and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Belumosudil belongs to Oncology; Enzalutamide belongs to Endocrine.
Why it happens
CYP3A4 induction by enzalutamide increases belumosudil metabolism.
What to do
Increase belumosudil to 200 mg twice daily during enzalutamide use and return to the usual dose after the inducer is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Belumosudil
- Amobarbital + Belumosudil Moderate
- Apalutamide + Belumosudil Moderate
- Armodafinil + Belumosudil Moderate
- Belumosudil + Bosentan Moderate
- Belumosudil + Carbamazepine Moderate
- Belumosudil + Dexlansoprazole Moderate
Frequently asked questions
Can I take Belumosudil with Enzalutamide?
MediHelp rates the interaction as moderate. Belumosudil and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide, a strong CYP3A4 inducer, lowers belumosudil exposure and may reduce control of chronic graft-versus-host disease.
How serious is the interaction between Belumosudil and Enzalutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Increase belumosudil to 200 mg twice daily during enzalutamide use and return to the usual dose after the inducer is stopped.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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