Drug interactions
Benazepril + Chlorpromazine
Severity: Minor
Benazepril and Chlorpromazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine has alpha-adrenergic blocking activity that can lower blood pressure. Combined with benazepril, the blood pressure lowering may be additive, with dizziness or orthostatic hypotension, particularly in older patients or at treatment start.
What this interaction means in plain words
Benazepril and Chlorpromazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Benazepril belongs to Cardiovascular; Chlorpromazine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic hypotension from alpha-1 blockade by chlorpromazine and ACE inhibition by benazepril.
What to do
Monitor blood pressure and orthostatic symptoms when starting or increasing either drug. Counsel patients to rise slowly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Benazepril with Chlorpromazine?
MediHelp rates the interaction as minor. Benazepril and Chlorpromazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chlorpromazine has alpha-adrenergic blocking activity that can lower blood pressure. Combined with benazepril, the blood pressure lowering may be additive, with dizziness or orthostatic hypotension, particularly in older patients or at treatment start.
How serious is the interaction between Benazepril and Chlorpromazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or increasing either drug. Counsel patients to rise slowly.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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