Drug interactions
Benazepril + Prochlorperazine
Severity: Minor
Benazepril and Prochlorperazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prochlorperazine has alpha-adrenergic blocking activity and can cause orthostatic hypotension. This may add to the blood pressure lowering effect of benazepril.
What this interaction means in plain words
Benazepril and Prochlorperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Benazepril belongs to Cardiovascular; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive hypotensive effect through alpha-adrenergic blockade combined with ACE inhibition.
What to do
Monitor blood pressure and orthostatic symptoms when starting or increasing prochlorperazine. Adjust the antihypertensive dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Prochlorperazine?
MediHelp rates the interaction as minor. Benazepril and Prochlorperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Prochlorperazine has alpha-adrenergic blocking activity and can cause orthostatic hypotension. This may add to the blood pressure lowering effect of benazepril.
How serious is the interaction between Benazepril and Prochlorperazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or increasing prochlorperazine. Adjust the antihypertensive dose if symptomatic hypotension occurs.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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