Drug interactions
Benazepril + Propofol
Severity: Moderate
Benazepril and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propofol causes vasodilation and myocardial depression, and ACE inhibitors blunt compensatory responses to hypotension. Patients taking benazepril may have more pronounced or refractory hypotension during induction of anesthesia.
What this interaction means in plain words
Benazepril and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Propofol belongs to Central Nervous System.
Why it happens
Additive vasodilation and blunted renin-angiotensin compensation, producing enhanced hypotension.
What to do
Monitor blood pressure continuously during induction and titrate propofol carefully. Have vasopressors and fluids available, and follow local protocols on holding the ACE inhibitor before surgery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Propofol
Frequently asked questions
Can I take Benazepril with Propofol?
MediHelp rates the interaction as moderate. Benazepril and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propofol causes vasodilation and myocardial depression, and ACE inhibitors blunt compensatory responses to hypotension. Patients taking benazepril may have more pronounced or refractory hypotension during induction of anesthesia.
How serious is the interaction between Benazepril and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure continuously during induction and titrate propofol carefully. Have vasopressors and fluids available, and follow local protocols on holding the ACE inhibitor before surgery.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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