Drug interactions
Benzathine penicillin g + Trofinetide
Severity: Minor
Benzathine penicillin g and Trofinetide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trofinetide may inhibit OATP1B1 and OATP1B3 and so raise levels of sensitive substrates. Penicillin G is not a notable OATP substrate and has a wide therapeutic index, so a clinically relevant effect is unlikely.
What this interaction means in plain words
Benzathine penicillin g and Trofinetide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Benzathine penicillin g belongs to Anti Bacterial; Trofinetide belongs to Central Nervous System.
Why it happens
Theoretical inhibition of hepatic OATP1B1/1B3 uptake by trofinetide.
What to do
No dose adjustment is needed. Monitor for penicillin adverse effects if the patient has other risk factors such as renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Benzathine penicillin g
- Benzathine penicillin g + Cholera vaccine Moderate
- Benzathine penicillin g + Microbiota Moderate
- Benzathine penicillin g + Omadacycline Moderate
- Benzathine penicillin g + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Amifampridine + Benzathine penicillin g Minor
Other interactions of Trofinetide
Frequently asked questions
Can I take Benzathine penicillin g with Trofinetide?
MediHelp rates the interaction as minor. Benzathine penicillin g and Trofinetide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Trofinetide may inhibit OATP1B1 and OATP1B3 and so raise levels of sensitive substrates. Penicillin G is not a notable OATP substrate and has a wide therapeutic index, so a clinically relevant effect is unlikely.
How serious is the interaction between Benzathine penicillin g and Trofinetide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for penicillin adverse effects if the patient has other risk factors such as renal impairment.
What other medicines interact with Benzathine penicillin g?
MediHelp also lists interactions of Benzathine penicillin g with, for example, Cholera vaccine, Microbiota, Omadacycline. The full list is on the Benzathine penicillin g page.
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