Drug interactions
Berotralstat + Ertugliflozin-sitagliptin
Severity: Minor
Berotralstat and Ertugliflozin-sitagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Berotralstat inhibits P-glycoprotein and may increase sitagliptin exposure. Sitagliptin has a wide therapeutic margin, so the increase is unlikely to be clinically significant.
What this interaction means in plain words
Berotralstat and Ertugliflozin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Berotralstat belongs to Miscellaneous; Ertugliflozin-sitagliptin belongs to Endocrine.
Why it happens
Inhibition of P-glycoprotein-mediated efflux of sitagliptin by berotralstat.
What to do
No routine dose change is needed. Monitor for sitagliptin adverse effects such as gastrointestinal symptoms and glycemic response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ertugliflozin-sitagliptin
Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Frequently asked questions
Can I take Berotralstat with Ertugliflozin-sitagliptin?
MediHelp rates the interaction as minor. Berotralstat and Ertugliflozin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Berotralstat inhibits P-glycoprotein and may increase sitagliptin exposure. Sitagliptin has a wide therapeutic margin, so the increase is unlikely to be clinically significant.
How serious is the interaction between Berotralstat and Ertugliflozin-sitagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for sitagliptin adverse effects such as gastrointestinal symptoms and glycemic response.
What other medicines interact with Ertugliflozin-sitagliptin?
MediHelp also lists interactions of Ertugliflozin-sitagliptin with, for example, Albiglutide, Aripiprazole, Asenapine. The full list is on the Ertugliflozin-sitagliptin page.
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