Drug interactions
Tenofovir alafenamide + Tepotinib
Severity: Moderate
Tenofovir alafenamide and Tepotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tepotinib inhibits P-gp and can increase exposure to P-gp substrates such as tenofovir alafenamide. Higher exposure could increase tenofovir-related renal or bone toxicity.
What this interaction means in plain words
Tenofovir alafenamide and Tepotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tenofovir alafenamide belongs to Anti Virals; Tepotinib belongs to Oncology.
Why it happens
Tepotinib inhibits intestinal P-gp efflux, increasing tenofovir alafenamide absorption.
What to do
Monitor renal function and tenofovir adverse effects; no empiric dose change is required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tenofovir alafenamide
- Apalutamide + Tenofovir alafenamide Major
- Berotralstat + Tenofovir alafenamide Moderate
- Danicopan + Tenofovir alafenamide Moderate
- Ifosfamide + Tenofovir alafenamide Moderate
- Orlistat + Tenofovir alafenamide Moderate
- Sotorasib + Tenofovir alafenamide Moderate
Other interactions of Tepotinib
- Colchicine + Tepotinib Major
- Digoxin + Tepotinib Major
- Tepotinib + Vincristine Major
- Amiodarone + Tepotinib Moderate
- Apixaban + Tepotinib Moderate
- Atorvastatin + Tepotinib Moderate
Frequently asked questions
Can I take Tenofovir alafenamide with Tepotinib?
MediHelp rates the interaction as moderate. Tenofovir alafenamide and Tepotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tepotinib inhibits P-gp and can increase exposure to P-gp substrates such as tenofovir alafenamide. Higher exposure could increase tenofovir-related renal or bone toxicity.
How serious is the interaction between Tenofovir alafenamide and Tepotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and tenofovir adverse effects; no empiric dose change is required.
What other medicines interact with Tenofovir alafenamide?
MediHelp also lists interactions of Tenofovir alafenamide with, for example, Apalutamide, Berotralstat, Danicopan. The full list is on the Tenofovir alafenamide page.
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