Drug interactions
Bicalutamide + Gepirone
Severity: Minor
Bicalutamide and Gepirone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gepirone is metabolized by CYP3A4 and its levels rise with CYP3A4 inhibitors, increasing dizziness and QT-related risk. Bicalutamide is only a weak inhibitor, so a significant effect is not expected.
What this interaction means in plain words
Bicalutamide and Gepirone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bicalutamide belongs to Endocrine; Gepirone belongs to Central Nervous System.
Why it happens
Possible weak inhibition of CYP3A4-mediated gepirone metabolism by bicalutamide.
What to do
No empirical dose change is needed; monitor for dizziness and adverse effects, and apply the labeled 50% gepirone reduction only if a true moderate CYP3A4 inhibitor effect is judged to be present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bicalutamide
- Bicalutamide + Lomitapide Major
- Aminolevulinic acid + Bicalutamide Moderate
- Bicalutamide + Eliglustat Moderate
- Bicalutamide + Flibanserin Moderate
- Bicalutamide + Ivosidenib Moderate
- Bicalutamide + Lonafarnib Moderate
Other interactions of Gepirone
- Clarithromycin + Gepirone Contraindicated
- Gepirone + Isocarboxazid Contraindicated
- Gepirone + Itraconazole Contraindicated
- Gepirone + Ketoconazole Contraindicated
- Gepirone + Linezolid Contraindicated
- Gepirone + Phenelzine Contraindicated
Frequently asked questions
Can I take Bicalutamide with Gepirone?
MediHelp rates the interaction as minor. Bicalutamide and Gepirone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Gepirone is metabolized by CYP3A4 and its levels rise with CYP3A4 inhibitors, increasing dizziness and QT-related risk. Bicalutamide is only a weak inhibitor, so a significant effect is not expected.
How serious is the interaction between Bicalutamide and Gepirone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; monitor for dizziness and adverse effects, and apply the labeled 50% gepirone reduction only if a true moderate CYP3A4 inhibitor effect is judged to be present.
What other medicines interact with Bicalutamide?
MediHelp also lists interactions of Bicalutamide with, for example, Lomitapide, Aminolevulinic acid, Eliglustat. The full list is on the Bicalutamide page.
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