Drug interactions
Bortezomib + Esomeprazole
Severity: Minor
Bortezomib and Esomeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bortezomib is metabolized by CYP2C19, CYP3A4 and CYP1A2, and it is not a recognized inhibitor of CYP2C19. A meaningful rise in esomeprazole exposure is not expected.
What this interaction means in plain words
Bortezomib and Esomeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bortezomib belongs to Oncology; Esomeprazole belongs to Gastrointestinal Tract.
Why it happens
No established mechanism; effect of bortezomib on esomeprazole's CYP2C19 metabolism is theoretical.
What to do
No adjustment is needed. Routine monitoring is sufficient.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Frequently asked questions
Can I take Bortezomib with Esomeprazole?
MediHelp rates the interaction as minor. Bortezomib and Esomeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bortezomib is metabolized by CYP2C19, CYP3A4 and CYP1A2, and it is not a recognized inhibitor of CYP2C19. A meaningful rise in esomeprazole exposure is not expected.
How serious is the interaction between Bortezomib and Esomeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed. Routine monitoring is sufficient.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
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