Drug interactions
Bortezomib + Fedratinib
Severity: Minor
Bortezomib and Fedratinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is metabolized by CYP3A4 and CYP2C19, and bortezomib is not a clinically established potent dual inhibitor of these enzymes. The legacy concern is therefore not well supported by known pharmacology. Both drugs can cause gastrointestinal toxicity and cytopenias, but no specific pharmacokinetic interaction is established.
What this interaction means in plain words
Bortezomib and Fedratinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bortezomib belongs to Oncology; Fedratinib belongs to Oncology.
Why it happens
No established pharmacokinetic mechanism; the interaction is theoretical.
What to do
No dose adjustment is needed. Monitor blood counts and neurologic status as routine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Bortezomib with Fedratinib?
MediHelp rates the interaction as minor. Bortezomib and Fedratinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fedratinib is metabolized by CYP3A4 and CYP2C19, and bortezomib is not a clinically established potent dual inhibitor of these enzymes. The legacy concern is therefore not well supported by known pharmacology. Both drugs can cause gastrointestinal toxicity and cytopenias, but no specific pharmacokinetic interaction is established.
How serious is the interaction between Bortezomib and Fedratinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor blood counts and neurologic status as routine.
What other medicines interact with Bortezomib?
MediHelp also lists interactions of Bortezomib with, for example, Apalutamide, Carbamazepine, Etrasimod. The full list is on the Bortezomib page.
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