Drug interactions
Bortezomib + Levoketoconazole
Severity: Moderate
Bortezomib and Levoketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 inhibitor. Ketoconazole has been shown to raise bortezomib exposure, so toxicity such as neuropathy and cytopenias may increase.
What this interaction means in plain words
Bortezomib and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bortezomib belongs to Oncology; Levoketoconazole belongs to Endocrine.
Why it happens
Levoketoconazole strongly inhibits CYP3A4, decreasing bortezomib metabolism.
What to do
Monitor closely for bortezomib toxicity and reduce the bortezomib dose if needed. Consider a non-inhibiting alternative where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Bortezomib with Levoketoconazole?
MediHelp rates the interaction as moderate. Bortezomib and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole is a strong CYP3A4 inhibitor. Ketoconazole has been shown to raise bortezomib exposure, so toxicity such as neuropathy and cytopenias may increase.
How serious is the interaction between Bortezomib and Levoketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for bortezomib toxicity and reduce the bortezomib dose if needed. Consider a non-inhibiting alternative where possible.
What other medicines interact with Bortezomib?
MediHelp also lists interactions of Bortezomib with, for example, Apalutamide, Carbamazepine, Etrasimod. The full list is on the Bortezomib page.
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