Drug interactions
Bortezomib + Modafinil
Severity: Minor
Bortezomib and Modafinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Modafinil may weakly inhibit CYP2C19, which contributes to bortezomib metabolism, so bortezomib exposure could rise slightly. The effect is predicted rather than well documented, and bortezomib has a narrow therapeutic window with neuropathy and cytopenias.
What this interaction means in plain words
Bortezomib and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bortezomib belongs to Oncology; Modafinil belongs to Central Nervous System.
Why it happens
Modafinil weakly inhibits CYP2C19, a minor pathway of bortezomib metabolism.
What to do
No empirical dose change is needed; monitor for bortezomib toxicity such as peripheral neuropathy, thrombocytopenia and gastrointestinal effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bortezomib and Modafinil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Modafinil
Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Frequently asked questions
Can I take Bortezomib with Modafinil?
MediHelp rates the interaction as minor. Bortezomib and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Modafinil may weakly inhibit CYP2C19, which contributes to bortezomib metabolism, so bortezomib exposure could rise slightly. The effect is predicted rather than well documented, and bortezomib has a narrow therapeutic window with neuropathy and cytopenias.
How serious is the interaction between Bortezomib and Modafinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; monitor for bortezomib toxicity such as peripheral neuropathy, thrombocytopenia and gastrointestinal effects.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
