Drug interactions
Bortezomib + Stiripentol
Severity: Moderate
Bortezomib and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits CYP2C19 and has mixed inhibitory and inducing effects on CYP3A4, so bortezomib exposure may rise or fall. This could change either toxicity or efficacy.
What this interaction means in plain words
Bortezomib and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bortezomib belongs to Oncology; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol inhibits CYP2C19 and CYP3A4 and may induce CYP3A4, altering bortezomib metabolism unpredictably.
What to do
Monitor for bortezomib toxicity, including neuropathy and cytopenias, and for loss of response, and adjust the dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Bortezomib with Stiripentol?
MediHelp rates the interaction as moderate. Bortezomib and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits CYP2C19 and has mixed inhibitory and inducing effects on CYP3A4, so bortezomib exposure may rise or fall. This could change either toxicity or efficacy.
How serious is the interaction between Bortezomib and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bortezomib toxicity, including neuropathy and cytopenias, and for loss of response, and adjust the dose accordingly.
What other medicines interact with Bortezomib?
MediHelp also lists interactions of Bortezomib with, for example, Apalutamide, Carbamazepine, Etrasimod. The full list is on the Bortezomib page.
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