Drug interactions
Bosentan + Calcifediol
Severity: Minor
Bosentan and Calcifediol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzyme-inducing drugs can accelerate calcifediol hydroxylation and shorten its half-life. Bosentan is a weak-to-moderate inducer, so any effect on vitamin D status is likely small.
What this interaction means in plain words
Bosentan and Calcifediol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bosentan belongs to Miscellaneous; Calcifediol belongs to Musculoskeletal.
Why it happens
Bosentan-mediated CYP3A4 induction may increase calcifediol catabolism.
What to do
Monitor serum 25-hydroxyvitamin D and calcium periodically and adjust the dose if levels fall.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Calcifediol
- Amlodipine-hydrochlorothiazide-valsartan + Calcifediol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcifediol Moderate
- Amobarbital + Calcifediol Moderate
- Atenolol-chlorthalidone + Calcifediol Moderate
- Azilsartan-chlorthalidone + Calcifediol Moderate
- Calcifediol + Candesartan-hydrochlorothiazide Moderate
Frequently asked questions
Can I take Bosentan with Calcifediol?
MediHelp rates the interaction as minor. Bosentan and Calcifediol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Enzyme-inducing drugs can accelerate calcifediol hydroxylation and shorten its half-life. Bosentan is a weak-to-moderate inducer, so any effect on vitamin D status is likely small.
How serious is the interaction between Bosentan and Calcifediol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum 25-hydroxyvitamin D and calcium periodically and adjust the dose if levels fall.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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