Drug interactions
Bosentan + Doravirine
Severity: Moderate
Bosentan and Doravirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan may lower doravirine concentrations, risking loss of virologic suppression and resistance.
What this interaction means in plain words
Bosentan and Doravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Doravirine belongs to Anti Virals.
Why it happens
CYP3A4 induction by bosentan increases doravirine metabolism.
What to do
Consider increasing doravirine to twice daily as for moderate inducers or use alternative therapy, and monitor HIV viral load.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Doravirine
- Amobarbital + Doravirine Contraindicated
- Apalutamide + Doravirine Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Doravirine + Efavirenz Contraindicated
- Doravirine + Enzalutamide Contraindicated
- Doravirine + Mitotane Contraindicated
Frequently asked questions
Can I take Bosentan with Doravirine?
MediHelp rates the interaction as moderate. Bosentan and Doravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan may lower doravirine concentrations, risking loss of virologic suppression and resistance.
How serious is the interaction between Bosentan and Doravirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider increasing doravirine to twice daily as for moderate inducers or use alternative therapy, and monitor HIV viral load.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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