Drug interactions
Bosentan + Elagolix
Severity: Moderate
Bosentan and Elagolix: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs induce CYP3A4 and each is a substrate, so exposure to both may fall. Reduced elagolix efficacy and reduced bosentan effect on pulmonary hypertension are possible.
What this interaction means in plain words
Bosentan and Elagolix can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Elagolix belongs to Musculoskeletal.
Why it happens
Mutual CYP3A4 induction increases metabolism of both drugs.
What to do
Monitor pain or bleeding control on elagolix and clinical status and exercise capacity on bosentan. Adjust therapy if efficacy is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Bosentan with Elagolix?
MediHelp rates the interaction as moderate. Bosentan and Elagolix can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs induce CYP3A4 and each is a substrate, so exposure to both may fall. Reduced elagolix efficacy and reduced bosentan effect on pulmonary hypertension are possible.
How serious is the interaction between Bosentan and Elagolix?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pain or bleeding control on elagolix and clinical status and exercise capacity on bosentan. Adjust therapy if efficacy is lost.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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