Drug interactions
Bosentan + Enzalutamide
Severity: Moderate
Bosentan and Enzalutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A4 and CYP2C9 inducer and can lower bosentan exposure, which may reduce efficacy in pulmonary arterial hypertension. Bosentan, a moderate inducer, may also modestly lower enzalutamide levels.
What this interaction means in plain words
Bosentan and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Enzalutamide belongs to Endocrine.
Why it happens
Enzalutamide induces CYP3A4 and CYP2C9, increasing bosentan metabolism; bosentan weakly induces CYP3A4.
What to do
Monitor PAH clinical response and consider alternative therapy if efficacy falls; also monitor liver function, as bosentan is hepatotoxic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Enzalutamide?
MediHelp rates the interaction as moderate. Bosentan and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide is a strong CYP3A4 and CYP2C9 inducer and can lower bosentan exposure, which may reduce efficacy in pulmonary arterial hypertension. Bosentan, a moderate inducer, may also modestly lower enzalutamide levels.
How serious is the interaction between Bosentan and Enzalutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor PAH clinical response and consider alternative therapy if efficacy falls; also monitor liver function, as bosentan is hepatotoxic.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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