Drug interactions
Bosentan + Maraviroc
Severity: Moderate
Bosentan and Maraviroc: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maraviroc is a CYP3A4 substrate, and inducers lower its levels. Bosentan, a moderate inducer, may reduce maraviroc exposure and the antiviral effect.
What this interaction means in plain words
Bosentan and Maraviroc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Maraviroc belongs to Anti Virals.
Why it happens
Bosentan induces CYP3A4, increasing maraviroc metabolism.
What to do
Monitor HIV viral load and consider adjusting maraviroc dose per labeling for use with inducers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Maraviroc
- Amobarbital + Maraviroc Major
- Apalutamide + Maraviroc Major
- Carbamazepine + Maraviroc Major
- Clarithromycin + Maraviroc Major
- Efavirenz + Maraviroc Major
- Enzalutamide + Maraviroc Major
Frequently asked questions
Can I take Bosentan with Maraviroc?
MediHelp rates the interaction as moderate. Bosentan and Maraviroc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maraviroc is a CYP3A4 substrate, and inducers lower its levels. Bosentan, a moderate inducer, may reduce maraviroc exposure and the antiviral effect.
How serious is the interaction between Bosentan and Maraviroc?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor HIV viral load and consider adjusting maraviroc dose per labeling for use with inducers.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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