Drug interactions
Bosentan + Tasimelteon
Severity: Moderate
Bosentan and Tasimelteon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tasimelteon is cleared by CYP3A4 and CYP1A2, and induction may lower exposure and reduce its effect on Non-24 sleep-wake disorder. Bosentan is a moderate rather than strong inducer, so the effect is likely smaller.
What this interaction means in plain words
Bosentan and Tasimelteon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Tasimelteon belongs to Central Nervous System.
Why it happens
Bosentan induces CYP3A4, increasing the metabolism of tasimelteon.
What to do
Monitor for reduced tasimelteon efficacy and consider alternative therapy if response is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Tasimelteon
Frequently asked questions
Can I take Bosentan with Tasimelteon?
MediHelp rates the interaction as moderate. Bosentan and Tasimelteon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tasimelteon is cleared by CYP3A4 and CYP1A2, and induction may lower exposure and reduce its effect on Non-24 sleep-wake disorder. Bosentan is a moderate rather than strong inducer, so the effect is likely smaller.
How serious is the interaction between Bosentan and Tasimelteon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced tasimelteon efficacy and consider alternative therapy if response is lost.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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