Drug interactions
Bosentan + Ticlopidine
Severity: Minor
Bosentan and Ticlopidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan is a CYP3A4 inducer, which could modestly lower exposure to CYP3A4-metabolized drugs. Ticlopidine's metabolism involves several enzymes, so any clinical effect on its antiplatelet activity is likely small.
What this interaction means in plain words
Bosentan and Ticlopidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bosentan belongs to Miscellaneous; Ticlopidine belongs to Cardiovascular.
Why it happens
Possible induction of CYP3A4 by bosentan increasing ticlopidine clearance.
What to do
No routine adjustment; watch for reduced antiplatelet effect in high-risk patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ticlopidine
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Ticlopidine?
MediHelp rates the interaction as minor. Bosentan and Ticlopidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bosentan is a CYP3A4 inducer, which could modestly lower exposure to CYP3A4-metabolized drugs. Ticlopidine's metabolism involves several enzymes, so any clinical effect on its antiplatelet activity is likely small.
How serious is the interaction between Bosentan and Ticlopidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment; watch for reduced antiplatelet effect in high-risk patients.
What other medicines interact with Ticlopidine?
MediHelp also lists interactions of Ticlopidine with, for example, Mavacamten, Abrocitinib, Acetylsalicylic acid. The full list is on the Ticlopidine page.
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