Drug interactions
Bosentan + Toremifene
Severity: Moderate
Bosentan and Toremifene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Toremifene is cleared by CYP3A4, and bosentan may lower its steady-state concentrations, potentially reducing efficacy.
What this interaction means in plain words
Bosentan and Toremifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Toremifene belongs to Endocrine.
Why it happens
Bosentan induces CYP3A4, increasing the metabolism of toremifene.
What to do
Monitor oncologic response, and consider an alternative to bosentan if possible. Toremifene dose increases are not routinely needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Toremifene
- Amiodarone + Toremifene Contraindicated
- Dronedarone + Toremifene Contraindicated
- Nilotinib + Toremifene Contraindicated
- Pimozide + Toremifene Contraindicated
- Quinidine + Toremifene Contraindicated
- Ribociclib + Toremifene Contraindicated
Frequently asked questions
Can I take Bosentan with Toremifene?
MediHelp rates the interaction as moderate. Bosentan and Toremifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Toremifene is cleared by CYP3A4, and bosentan may lower its steady-state concentrations, potentially reducing efficacy.
How serious is the interaction between Bosentan and Toremifene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor oncologic response, and consider an alternative to bosentan if possible. Toremifene dose increases are not routinely needed.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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