Drug interactions
Bosentan + Ubrogepant
Severity: Moderate
Bosentan and Ubrogepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan may lower ubrogepant concentrations through CYP3A4 induction. This may reduce its effect in acute migraine treatment.
What this interaction means in plain words
Bosentan and Ubrogepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Ubrogepant belongs to Central Nervous System.
Why it happens
Bosentan induces CYP3A4, increasing ubrogepant metabolism.
What to do
Avoid strong inducers; with bosentan, consider ubrogepant 100 mg dosing per labeling for moderate inducers and monitor migraine response. Choose an alternative acute therapy if efficacy is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Ubrogepant
- Clarithromycin + Ubrogepant Contraindicated
- Itraconazole + Ubrogepant Contraindicated
- Ketoconazole + Ubrogepant Contraindicated
- Posaconazole + Ubrogepant Contraindicated
- Ubrogepant + Voriconazole Contraindicated
- Apalutamide + Ubrogepant Major
Frequently asked questions
Can I take Bosentan with Ubrogepant?
MediHelp rates the interaction as moderate. Bosentan and Ubrogepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan may lower ubrogepant concentrations through CYP3A4 induction. This may reduce its effect in acute migraine treatment.
How serious is the interaction between Bosentan and Ubrogepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid strong inducers; with bosentan, consider ubrogepant 100 mg dosing per labeling for moderate inducers and monitor migraine response. Choose an alternative acute therapy if efficacy is inadequate.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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