Drug interactions
Bremelanotide + Dihydroergotamine
Severity: Minor
Bremelanotide and Dihydroergotamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bremelanotide can slow gastric emptying and thereby delay or reduce absorption of oral medicines. For oral dihydroergotamine this may lessen or delay migraine relief, while bremelanotide's own blood pressure effects should also be considered.
What this interaction means in plain words
Bremelanotide and Dihydroergotamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bremelanotide belongs to Genitourinary; Dihydroergotamine belongs to Central Nervous System.
Why it happens
Delayed gastric emptying from bremelanotide may reduce absorption of orally administered dihydroergotamine.
What to do
Monitor for reduced antimigraine response, and consider a non-oral dihydroergotamine route if efficacy is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bremelanotide
- Bremelanotide + Bupropion-naltrexone Moderate
- Bremelanotide + Cyclosporin Moderate
- Bremelanotide + Digoxin Moderate
- Bremelanotide + Disopyramide Moderate
- Bremelanotide + Naltrexone Moderate
- Bremelanotide + Procainamide Moderate
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
Frequently asked questions
Can I take Bremelanotide with Dihydroergotamine?
MediHelp rates the interaction as minor. Bremelanotide and Dihydroergotamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bremelanotide can slow gastric emptying and thereby delay or reduce absorption of oral medicines. For oral dihydroergotamine this may lessen or delay migraine relief, while bremelanotide's own blood pressure effects should also be considered.
How serious is the interaction between Bremelanotide and Dihydroergotamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced antimigraine response, and consider a non-oral dihydroergotamine route if efficacy is lost.
What other medicines interact with Bremelanotide?
MediHelp also lists interactions of Bremelanotide with, for example, Bupropion-naltrexone, Cyclosporin, Digoxin. The full list is on the Bremelanotide page.
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