Drug interactions
Brentuximab + Enzalutamide
Severity: Minor
Brentuximab and Enzalutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A4 inducer and may lower exposure to MMAE released from brentuximab vedotin. Reduced exposure could lessen antitumor effect.
What this interaction means in plain words
Brentuximab and Enzalutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brentuximab belongs to Oncology; Enzalutamide belongs to Endocrine.
Why it happens
Strong CYP3A4 induction enhances MMAE metabolism.
What to do
No empiric dose change; monitor clinical response to brentuximab.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Brentuximab
- Bleomycin + Brentuximab Contraindicated
- Brentuximab + Dengue vaccine Major
- Brentuximab + Etrasimod Major
- Brentuximab + Idelalisib Major
- Brentuximab + Levoketoconazole Major
- Brentuximab + Nefazodone Major
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Brentuximab with Enzalutamide?
MediHelp rates the interaction as minor. Brentuximab and Enzalutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Enzalutamide is a strong CYP3A4 inducer and may lower exposure to MMAE released from brentuximab vedotin. Reduced exposure could lessen antitumor effect.
How serious is the interaction between Brentuximab and Enzalutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change; monitor clinical response to brentuximab.
What other medicines interact with Brentuximab?
MediHelp also lists interactions of Brentuximab with, for example, Bleomycin, Dengue vaccine, Etrasimod. The full list is on the Brentuximab page.
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