Drug interactions
Brentuximab + Posaconazole
Severity: Moderate
Brentuximab and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole is a strong CYP3A4 inhibitor and can raise exposure to MMAE, the cytotoxic payload of brentuximab vedotin. This may increase neutropenia and peripheral neuropathy.
What this interaction means in plain words
Brentuximab and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brentuximab belongs to Oncology; Posaconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4 by posaconazole reduces MMAE clearance.
What to do
Monitor closely for neutropenia and neuropathy, and check blood counts regularly during coadministration. Consider an alternative antifungal if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Brentuximab and Posaconazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Brentuximab
- Bleomycin + Brentuximab Contraindicated
- Brentuximab + Dengue vaccine Major
- Brentuximab + Etrasimod Major
- Brentuximab + Idelalisib Major
- Brentuximab + Levoketoconazole Major
- Brentuximab + Nefazodone Major
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Brentuximab with Posaconazole?
MediHelp rates the interaction as moderate. Brentuximab and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole is a strong CYP3A4 inhibitor and can raise exposure to MMAE, the cytotoxic payload of brentuximab vedotin. This may increase neutropenia and peripheral neuropathy.
How serious is the interaction between Brentuximab and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for neutropenia and neuropathy, and check blood counts regularly during coadministration. Consider an alternative antifungal if toxicity develops.
What other medicines interact with Brentuximab?
MediHelp also lists interactions of Brentuximab with, for example, Bleomycin, Dengue vaccine, Etrasimod. The full list is on the Brentuximab page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
