Drug interactions
Brexpiprazole + Chloroquine
Severity: Moderate
Brexpiprazole and Chloroquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloroquine is a weak to moderate CYP2D6 inhibitor and may raise brexpiprazole exposure, since CYP2D6 is one of its two main clearance pathways. The effect is usually modest unless other inhibitors of CYP2D6 and CYP3A4 are also present, in which case exposure can rise substantially.
What this interaction means in plain words
Brexpiprazole and Chloroquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Chloroquine belongs to Anti Parasitic.
Why it happens
Inhibition of CYP2D6-mediated metabolism of brexpiprazole by chloroquine.
What to do
Monitor for increased sedation, akathisia and other adverse effects of brexpiprazole. Reduce the brexpiprazole dose to a quarter of the usual dose if a CYP2D6 inhibitor is combined with a strong or moderate CYP3A4 inhibitor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Brexpiprazole and Chloroquine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Chloroquine?
MediHelp rates the interaction as moderate. Brexpiprazole and Chloroquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloroquine is a weak to moderate CYP2D6 inhibitor and may raise brexpiprazole exposure, since CYP2D6 is one of its two main clearance pathways. The effect is usually modest unless other inhibitors of CYP2D6 and CYP3A4 are also present, in which case exposure can rise substantially.
How serious is the interaction between Brexpiprazole and Chloroquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation, akathisia and other adverse effects of brexpiprazole. Reduce the brexpiprazole dose to a quarter of the usual dose if a CYP2D6 inhibitor is combined with a strong or moderate CYP3A4 inhibitor.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
