Drug interactions
Brexpiprazole + Duloxetine
Severity: Moderate
Brexpiprazole and Duloxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duloxetine is a moderate CYP2D6 inhibitor and brexpiprazole is cleared in part by CYP2D6, so brexpiprazole exposure may increase, with more sedation, akathisia or other adverse effects. The effect is larger if a CYP3A4 inhibitor is also given.
What this interaction means in plain words
Brexpiprazole and Duloxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Duloxetine belongs to Central Nervous System.
Why it happens
Inhibition of CYP2D6-mediated brexpiprazole metabolism by duloxetine.
What to do
Monitor for brexpiprazole adverse effects and consider a dose reduction, as labeling advises. Reduce the dose further if a CYP3A4 inhibitor is also used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Duloxetine?
MediHelp rates the interaction as moderate. Brexpiprazole and Duloxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duloxetine is a moderate CYP2D6 inhibitor and brexpiprazole is cleared in part by CYP2D6, so brexpiprazole exposure may increase, with more sedation, akathisia or other adverse effects. The effect is larger if a CYP3A4 inhibitor is also given.
How serious is the interaction between Brexpiprazole and Duloxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for brexpiprazole adverse effects and consider a dose reduction, as labeling advises. Reduce the dose further if a CYP3A4 inhibitor is also used.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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