Drug interactions
Brexpiprazole + Fenfluramine
Severity: Moderate
Brexpiprazole and Fenfluramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenfluramine can cause somnolence and lethargy, which may add to brexpiprazole sedation. Both drugs act on serotonergic systems, so additive effects on mood and neuropsychiatric status are possible.
What this interaction means in plain words
Brexpiprazole and Fenfluramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Fenfluramine belongs to Central Nervous System.
Why it happens
Additive CNS depression; overlapping serotonergic activity.
What to do
Monitor for excess sedation and for signs of serotonergic toxicity. Reduce doses if daytime impairment develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Brexpiprazole with Fenfluramine?
MediHelp rates the interaction as moderate. Brexpiprazole and Fenfluramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenfluramine can cause somnolence and lethargy, which may add to brexpiprazole sedation. Both drugs act on serotonergic systems, so additive effects on mood and neuropsychiatric status are possible.
How serious is the interaction between Brexpiprazole and Fenfluramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and for signs of serotonergic toxicity. Reduce doses if daytime impairment develops.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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