Drug interactions
Brexpiprazole + Fexofenadine
Severity: Minor
Brexpiprazole and Fexofenadine: minor interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brexpiprazole may cause somnolence, and fexofenadine rarely does. Any added sedation is expected to be minimal.
What this interaction means in plain words
Brexpiprazole and Fexofenadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brexpiprazole belongs to Central Nervous System; Fexofenadine belongs to Respiratory.
Why it happens
Possible additive CNS depression; fexofenadine is non-sedating at usual doses.
What to do
No routine action is needed. Advise patients to report excessive drowsiness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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References
- Rexulti - FDA drug label (DailyMed) — openFDA / DailyMed
Other interactions of Fexofenadine
- Danicopan + Fexofenadine Moderate
- Erdafitinib + Fexofenadine Moderate
- Fexofenadine + Glecaprevir / pibrentasvir Moderate
- Fexofenadine + Grapefruit Moderate
- Fexofenadine + Juice Moderate
- Acrivastine + Fexofenadine Minor
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Fexofenadine?
MediHelp rates the interaction as minor. Brexpiprazole and Fexofenadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Brexpiprazole may cause somnolence, and fexofenadine rarely does. Any added sedation is expected to be minimal.
How serious is the interaction between Brexpiprazole and Fexofenadine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Advise patients to report excessive drowsiness.
What other medicines interact with Fexofenadine?
MediHelp also lists interactions of Fexofenadine with, for example, Danicopan, Erdafitinib, Glecaprevir / pibrentasvir. The full list is on the Fexofenadine page.
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