Drug interactions
Brexpiprazole + Idelalisib
Severity: Major
Brexpiprazole and Idelalisib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A4 inhibitor and can markedly increase brexpiprazole exposure. This raises the risk of akathisia, sedation, orthostatic hypotension and other dose-related effects.
What this interaction means in plain words
Brexpiprazole and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Brexpiprazole belongs to Central Nervous System; Idelalisib belongs to Oncology.
Why it happens
Strong inhibition of CYP3A4-mediated brexpiprazole metabolism.
What to do
Give half of the usual brexpiprazole dose, or a quarter if a CYP2D6 inhibitor is also given. Monitor for adverse effects and restore the dose after idelalisib is stopped.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Brexpiprazole
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Brexpiprazole with Idelalisib?
MediHelp rates the interaction as major. Brexpiprazole and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Idelalisib is a strong CYP3A4 inhibitor and can markedly increase brexpiprazole exposure. This raises the risk of akathisia, sedation, orthostatic hypotension and other dose-related effects.
How serious is the interaction between Brexpiprazole and Idelalisib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give half of the usual brexpiprazole dose, or a quarter if a CYP2D6 inhibitor is also given. Monitor for adverse effects and restore the dose after idelalisib is stopped.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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