Drug interactions
Brexpiprazole + Mirtazapine
Severity: Moderate
Brexpiprazole and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation and somnolence, so taking them together can intensify drowsiness and impair alertness and psychomotor performance. Combined use is common in augmentation of depression treatment but the added CNS depression matters for driving and fall risk.
What this interaction means in plain words
Brexpiprazole and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Mirtazapine belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects from histamine H1 and other receptor antagonism.
What to do
Monitor for excessive sedation and orthostatic symptoms, particularly at initiation or dose increases. Counsel patients about driving and operating machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Mirtazapine?
MediHelp rates the interaction as moderate. Brexpiprazole and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation and somnolence, so taking them together can intensify drowsiness and impair alertness and psychomotor performance. Combined use is common in augmentation of depression treatment but the added CNS depression matters for driving and fall risk.
How serious is the interaction between Brexpiprazole and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and orthostatic symptoms, particularly at initiation or dose increases. Counsel patients about driving and operating machinery.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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