Drug interactions
Brexpiprazole + Nevirapine
Severity: Moderate
Brexpiprazole and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine can lower brexpiprazole concentrations and may reduce antipsychotic or antidepressant-augmenting effect. This may increase the risk of relapse or inadequate response.
What this interaction means in plain words
Brexpiprazole and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Nevirapine belongs to Anti Virals.
Why it happens
Nevirapine induces CYP3A4, which is a main metabolic pathway of brexpiprazole.
What to do
Monitor psychiatric response and consider raising the brexpiprazole dose as advised for CYP3A4 inducers. Reduce the dose back to baseline over 1-2 weeks if nevirapine is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Nevirapine?
MediHelp rates the interaction as moderate. Brexpiprazole and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine can lower brexpiprazole concentrations and may reduce antipsychotic or antidepressant-augmenting effect. This may increase the risk of relapse or inadequate response.
How serious is the interaction between Brexpiprazole and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor psychiatric response and consider raising the brexpiprazole dose as advised for CYP3A4 inducers. Reduce the dose back to baseline over 1-2 weeks if nevirapine is stopped.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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