Drug interactions
Brexpiprazole + Panobinostat
Severity: Minor
Brexpiprazole and Panobinostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Panobinostat is a weak CYP2D6 inhibitor and might slightly raise brexpiprazole exposure. The effect is unlikely to be significant alone.
What this interaction means in plain words
Brexpiprazole and Panobinostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brexpiprazole belongs to Central Nervous System; Panobinostat belongs to Oncology.
Why it happens
Weak CYP2D6 inhibition by panobinostat may reduce brexpiprazole metabolism.
What to do
No routine dose change is needed; monitor for adverse effects. Reduce brexpiprazole dose if a CYP3A4 inhibitor is also being taken.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Brexpiprazole
Other interactions of Panobinostat
- Amiodarone + Panobinostat Contraindicated
- Anagrelide + Panobinostat Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
- Dronedarone + Panobinostat Contraindicated
- Haloperidol + Panobinostat Contraindicated
Frequently asked questions
Can I take Brexpiprazole with Panobinostat?
MediHelp rates the interaction as minor. Brexpiprazole and Panobinostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Panobinostat is a weak CYP2D6 inhibitor and might slightly raise brexpiprazole exposure. The effect is unlikely to be significant alone.
How serious is the interaction between Brexpiprazole and Panobinostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for adverse effects. Reduce brexpiprazole dose if a CYP3A4 inhibitor is also being taken.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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