Drug interactions
Brexpiprazole + Pregabalin
Severity: Moderate
Brexpiprazole and Pregabalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, and combined use can increase sedation, dizziness and cognitive impairment. Pregabalin has been linked to respiratory depression when given with other CNS depressants, particularly in older patients or those with respiratory compromise.
What this interaction means in plain words
Brexpiprazole and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Pregabalin belongs to Central Nervous System.
Why it happens
Additive CNS depression via different pharmacodynamic mechanisms.
What to do
Use the lowest effective doses and titrate slowly. Monitor for sedation and respiratory depression, especially in older patients or those with lung disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Other interactions of Pregabalin
Frequently asked questions
Can I take Brexpiprazole with Pregabalin?
MediHelp rates the interaction as moderate. Brexpiprazole and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, and combined use can increase sedation, dizziness and cognitive impairment. Pregabalin has been linked to respiratory depression when given with other CNS depressants, particularly in older patients or those with respiratory compromise.
How serious is the interaction between Brexpiprazole and Pregabalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and titrate slowly. Monitor for sedation and respiratory depression, especially in older patients or those with lung disease.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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