Drug interactions
Brexpiprazole + Ranolazine
Severity: Moderate
Brexpiprazole and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine is a weak to moderate CYP2D6 inhibitor and can raise brexpiprazole exposure, which is cleared by CYP2D6 and CYP3A4. The effect is mainly relevant when other inhibitors are present, such as in CYP2D6 poor metabolizers or with strong CYP3A4 inhibitors.
What this interaction means in plain words
Brexpiprazole and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Ranolazine belongs to Cardiovascular.
Why it happens
Inhibition of CYP2D6-mediated brexpiprazole metabolism by ranolazine, increasing brexpiprazole exposure.
What to do
Watch for akathisia, sedation and orthostatic hypotension; reduce the brexpiprazole dose according to labeling if ranolazine is combined with other CYP2D6 or CYP3A4 inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Brexpiprazole and Ranolazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Ranolazine?
MediHelp rates the interaction as moderate. Brexpiprazole and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ranolazine is a weak to moderate CYP2D6 inhibitor and can raise brexpiprazole exposure, which is cleared by CYP2D6 and CYP3A4. The effect is mainly relevant when other inhibitors are present, such as in CYP2D6 poor metabolizers or with strong CYP3A4 inhibitors.
How serious is the interaction between Brexpiprazole and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for akathisia, sedation and orthostatic hypotension; reduce the brexpiprazole dose according to labeling if ranolazine is combined with other CYP2D6 or CYP3A4 inhibitors.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
